Top latest Five rheumatoid arthritis causes Urban news


The immune system of many people is failing to distinguish between healthy cells from invading micro-organisms. This is creating more suffering across the globe. Instead of protecting themselves from illness, their organs and tissue are attacked by these same defenses.




Research efforts across the globe are increasing to combat this trend. A prime example is the London Francis Crick Institute initiative where James Lee and Carola Vinesa two experts from around the world in the field, have established separate research groups to aid in determining the precise nature of the autoimmune disorders.


Lee told the Observer that cases of autoimmune disease increased in the west about 40 years ago. But, we're now witnessing cases appear in countries that never had these diseases prior to.


For example, the Middle East/East Asia is the region that has seen the highest recent rise in the number of inflammatory bowel disease cases. The people there had never heard of the disease prior to.


Type 1 diabetes is one of the autoimmune disorders. Other conditions include rheumatoid arthritis, inflammatory bowel and multiple sclerosis. In each case the immune system has its wires crossed and focuses on healthy tissue instead of infective agents.


At least 4 million people in the UK suffer from these diseases. Other people may have more than one. It is estimated that autoimmune diseases increase by anywhere from 3% to 9% per year worldwide. The rise in cases of autoimmune diseases is believed to be caused by environmental factors, according to the majority of researchers.


Lee, who was once located at Cambridge University, stated that human genetics have not changed in the last couple of decades. Therefore, something is changing outside of our body that may increase our chances of developing an autoimmune disease.


Vinuesa who was based at Australia National University, endorsed the notion. She pointed out the changes in the way people eat as more nations were adopting western eating habits, and people were eating much more fast-food.


Fast-food diets lack certain important ingredients, such as fiber, and research suggests that this can affect the microbiome of a person - the micro-organisms reside within our guts and that are essential in controlling various body functions, Vinuesa explained.


These changes to our microbiomes then trigger an autoimmune disease, and more than 100 kinds have now been discovered.


The two scientists also stressed that everyone is at risk of developing these illnesses, which include celiac, Lupus, and various other illnesses, such as celiac, that cause swelling and inflammation and can cause serious damage to the organs of various.


"If you don't have a specific genetic susceptibility to autoimmune disease, you won't necessarily get an autoimmune disorder regardless of the amount of Big Macs you Click here consume," said Vinuesa. "There's nothing we can do to stop the worldwide spread of fast food franchises. Instead, we're focused on the genetic arthritis rheumatoid juvenile elements that trigger autoimmune disorders. We want to know the reasons why certain people are more vulnerable than others. "We would like to tackle the issue on a fundamental level."


With the help of modern technology, scientists are now able to identify small genetic differences between large numbers of individuals. This allows them to recognize common genetic patterns that are common to people with an autoimmune disorder.


Lee explained that until recently , we did not have the tools to sequence DNA. But now, we have this amazing power and it has changed everything. When I started my research, we only knew about 50% of the DNA variants that are involved in the development of inflammatory intestinal disease. We now know about 250.


Lee and Vinuesa are pursuing such work because they want to know how the genetic pathways function and the causes of the various illnesses that doctors are currently looking into. Vinuesa stated that autoimmune disorders like Lupus, for instance are present in various forms and could have different genetic causes. If you're trying to determine the best treatment for your condition, this could be an issue.


We are blessed with a wealth of beneficial therapies being developed constantly, but we don't know what patients to recommend the treatments, as we've realized that we don't know exactly which type of disease they are suffering from. This is an important goal in autoimmune research. It is important to understand how to stratify and group patients in order to give them the appropriate treatment.


Lee explained that the increasing incidence of autoimmune diseases across the world means new treatments and medications are needed now more than ever before. There is currently no treatment for autoimmune disease that are most often seen in young peoplewho are trying to get their first job, finish school, and take care of their families.


This means that more and more of people will need undergo surgery or receive regular injections. It's a bleak time for patients and a massive pressure on health services. So, it is essential to discover effective and innovative methods of treatment.


Rheumatoid arthritis is an auto-immune condition. This means the immune system is attacking healthy tissue. However, it's not clear what causes it.


Your immune system naturally produces antibodies to fight bacteria and viruses.


Your immune system may mistakenly send antibodies to your joints in the event that you suffer from Rheumatoid. The antibodies attack surrounding tissue.


This causes the thin layer, or synovium of cells that surround your joints to become sore. It also releases chemicals that could cause injury nearby.


bones

Cartilage is the connective tissue that joins cartilage and bones

Tendons - connects muscle to bone

Ligaments These are the tissues that connects the cartilage to bones.

If rheumatoid joint disease isn't treated, these chemicals slowly make the joint lose its shape and alignment. It could eventually cause the destruction of the joint.


While there are many theories on how the immune system attacks the joint, none have been proven.


Possible risk factors



You may be at a higher risk of developing rheumatoid arthritis If you have the following habits:


the genes you carry - there's evidence to suggest that rheumatoid arthritis may be passed down in families, though the likelihood of passing it on is thought to be low because genes are thought to play a minor part in the disease

Hormones Rheumatoid arthritis is more common for women than men. Though this could be due in part to the effects estrogenic hormones on the body, the cause has not been established.

Smoking - Some evidence suggests that smokers are at a higher risk of developing rheumatoidarthritis.

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